D. S. Senanayake College, situated in Colombo 7, is a public national school in Sri Lanka. It is named after the first Prime Minister of Independent Sri Lanka, Don Stephen Senanayake. It was established on February 10, 1967 under the stewardship of Ralph Ignatius Thomas Alles. As a national school, it is controlled by the central government, as opposed to a provincial council.

The School has current enrollment of over 6000 students with an academic staff over 275. The school is listed among the National Schools, which come under the administration of the Ministry of Education, thus has direct funding from the ministry. The School provides education to students from Grade 1 to 13 in Sinhala, Tamil and English languages. It also provides Mathematics, Science, Commerce, Arts and Technology (pls check if this is correct) fields for the G. C. E. Advance Level Examinations. The school is fully equipped with Modern Classrooms, Multiple Science Laboratories and Computer Laboratories, (how about libraries?) Grounds & Sports Complex for sports activities. While providing a wide range of sporting activities for the students, the School also has more than 35 Clubs, Societies & Associations engaged in all types of co-curricular activities.